Valsartan hydrochlorothiazide generic drug, rifampin, rifabutin, streptomycin, amoxicillin and gentamicin, daptomycin, oxacillin, cefazolin, cefotaxime; and in addition, levofloxacin and clarithromycin. Treatment-Emergent Adverse Reactions Symptoms that develop 1 to 24 hours after initiation of the recommended dosage an antibiotic are described as treatment-emergent adverse reactions. reactions to nontherapy-indicated courses of antimicrobial agents are termed nontherapeutic adverse reactions (NTU). Treatment-Emergent Adverse Reactions to Antitussive Agents A serious adverse reaction (SARe) is defined as a nonurgent condition that significantly reduces an individual's capacity to perform normal activities. Serious adverse reactions include the following: Achemedesis or altered cognition; Acute psychosis or other significant change in